It's been well documented on this and other forums that the Toyota ECU "learns" and that any mods to the air fuel ratios (i.e. through AFC's and other interceptors) are eventually dialled out so that you end up running too rich again.
Occasionally by resetting it (removing the EFI fuse) you go back to your original leaner tune.
1. Does the ECU change open loop maps? (Mine feels like it does, but I don't have dyno evidence)
2. If you leave your tuning adjustments for open loop / high in the RPM range / at high throttle settings, will your adjustments be more durable?
3. Does re-booting it all the time damage the ECU?
4. How often do you reset the ECU? What is your recommended methods?
I know that ultimately the best solution is full aftermarket management, but for various reasons lots of us don't have this capability.