What do you have available and what are you trying to build?
If you currently have a single cam 2T motor you can use your existing block, grinding reliefs for crank clearance when fitting crank.
If you've currently got a 2T-G, you can use your 2T-G block, but earlier blocks (220, 222, ~260 head numbers) will require crank clearance machining as described above.
3T block is same as later 2T blocks, so will fit 3T crank without machining. 3T-GT block will require modification to seal the oil return.
If you're using 2T-G head on your hybrid you should use a 2T-G block as supplimentary drive cam will suit your application. With creative fitment of cam bearings 3T-G block can be used.