right. you can turn the wheel tighter to inject less fuel if you have larger then stock injectors. But the ECU will only compensate for a small % before it can't handle it. Depending on the year and country of the 22RE it either has 182cc(grey in color) or 200cc(round plug, red in color) The 4age "blue" are 210cc and the 22RE ECU can adjust for them nicely. It's usually 3 teeth tigher on the wheel. And they plug right in and fit the fuel rail. They are also the same injectors on the 18RGEU's(blue 210cc)