As was proved above (oldcorollas), one would be pointless, two would probably work but simmilarly you would be a good chance of cooking the teflon off the lobes at high rpm because you will be on the threshold of over-spinning it to get decent boost.
I have heard of a good twin sc14 on an ol red 208. (never seen it tho, twas just a legend - woulda been a bitch to plumb efficiently i reckon with a straight six)